Cardiomyocytes Replicate and their Numbers Increase in Young Hearts

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Cardiomyocytes Replicate and their Numbers Increase in Young Hearts

Inmice, the heart nearly quadruples in size from early preadolescence (postnatal day 10 [P10]) to puberty ( P35) (Naqvi et al., 2014). Because it is widely believed that mammalian cardiomyocytes (CMs) are incapable of replication after birth, it has been assumed that early postnatal heart growth is driven solely by CM hypertrophy. Our findings question this view and provide insights into how th...

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ژورنال

عنوان ژورنال: Cell

سال: 2015

ISSN: 0092-8674

DOI: 10.1016/j.cell.2015.10.038